This painting was made between 1534 and 1538 for the Galleria della Accademia, Venice, Italy where it is currently located. When Tiziano made this big painting (345x775 cm) in Venice, who else but St.Jerome was portrayed in the very left of the painting, asking for some donation along with a little child, maybe an orphan? St.Jerome was a noble man, who began in Venice a very well known works for charities for orphans and needy youth. Around the time when Tiziano painted this artwork, St.Jerome was well known by all in Venice. Tiziano had his studio near one of those orphanages (San Rocco). It is with some certainty that the man on the left is St. Jerome Emiliani. St.Jerome died in 1537.
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